Information about GERD Symptoms, Diagnosis, Treatment options, and GERD Medication
For information on Irritable Bowel Syndrome (IBS) visit:



Irritable Bowel Syndrome (IBS)


Complications with Barrett's Esophagus *

Patient B: 42 year old male with severe heartburn. Endoscopy showed HH with severe exudative esophagitis. The patient was treated with high dose Omeprazole. Several months later endoscopy showed a 5 cm columnar mucosa. Biopsy showed high grade dysplasia as well as invasive carcinoma.

1. High grade dysplasia in Barrett’s esophagus (high power):

Figure 1

The high grade dysplasia is recognized by markedly atypical cells with large pleomorphic nuclei with prominent nucleoli and a loss of polarity within the epithelium. The epithelium is delimited by a basement membrane and surrounded by inflammatory cells, mostly plasma cells with a few lymphocytes and pmn’s.

2. Invasive adenocarcinoma in association with high grade dysplasia in Barrett’s esophagus (high power):

Figure 2

Small round glandular structures with atypical nuclei are present in an infiltrative pattern in a reactive fibrous stroma. High grade dysplasia is in the epithelium enclosed by the basement membrane in the upper left corner.

The following narrative provides more information on the relationship between Esophageal Adenocarcinoma and GERD: Epidemiology of Adenocarcinoma

* Pathology slides of our patients were provided by Dr. James P. Kolton of Caritas Norwood Hospital, Norwood, MA.







         This is an educational site created by M. Farivar, M.D. The information provided is the author's opinion based on years of clinical experience and research.  You are advised to consult your own physician about the applicability of this information to your particular needs.  Also, keep in mind that symptom response to therapy does not preclude the presence of more serious conditions. 

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